USMLE Step 2 CK Ep-1

Hypertension Management: Key Insights from the 2017 ACC/AHA Guidelines

Overview

The 2017 ACC/AHA guidelines focus on prevention, detection, evaluation, and management of high blood pressure (BP) in adults. These guidelines replace the 2003 JNC 7 recommendations and introduce significant updates, including the role of ambulatory/home BP monitoring, treatment thresholds, BP goals, and strategies for improving hypertension control.

BP Categorization

  • Normal BP: <120/<80 mmHg
  • Elevated BP: 120–129/<80 mmHg
  • Stage 1 Hypertension: 130–139/80–89 mmHg
  • Stage 2 Hypertension: ≥140/≥90 mmHg

Note: Diagnosis requires an average of ≥2 readings on different occasions. Either systolic or diastolic values qualifying is sufficient for staging.

Out-of-Office BP Monitoring

  • Strongly recommended for accurate diagnosis and prognosis.
  • Methods:
    • Ambulatory BP Monitoring (ABPM): Gold standard but less convenient.
    • Home BP Monitoring (HBPM): Practical and reliable when validated devices are used.

BP Patterns

  • Normal Tension: Normal BP in both office and home settings.
  • Sustained Hypertension: Elevated BP in both settings.
  • White Coat Hypertension: Elevated office BP but normal home BP.
  • Masked Hypertension: Normal office BP but elevated home BP.

Hypertension and Cardiovascular Risk

  • Continuous BP elevation is a significant independent risk factor for cardiovascular disease (CVD).
  • Risk doubles with each 20 mmHg systolic or 10 mmHg diastolic rise above 115/75 mmHg.
  • Hypertension is a leading cause of mortality globally, surpassing other risks like smoking and high blood sugar.

Types of Hypertension

  1. Primary Hypertension: Idiopathic; associated with age-related factors and arteriosclerosis.
  2. Secondary Hypertension: Caused by underlying conditions (e.g., renal artery stenosis, pheochromocytoma, hyperaldosteronism).
  3. Resistant Hypertension: Uncontrolled BP despite three medications, including a diuretic.

Screening for Secondary Hypertension

Screen for secondary causes if:

  • Onset before age 30 or abrupt worsening.
  • Resistant hypertension.
  • Associated symptoms (e.g., hypokalemia, adrenal nodules, headaches, palpitations).

Common Cause: Primary Hyperaldosteronism, prevalent in 5–10% of new hypertensives and 20–25% of resistant cases.

Recommended Tests

  • Basic: Fasting blood glucose, lipid profile, CMP, CBC, thyroid function, urinalysis, EKG.
  • Optional: Echocardiogram, uric acid, urinary albumin-to-creatinine ratio.

BP Management Goals

  • Target BP: <130/80 mmHg for most adults.
  • Lifestyle Modifications:
    • Sodium reduction.
    • Regular physical activity.
    • Weight management.

Therapeutic Highlights

  • Every 5 mmHg BP reduction decreases CVD risk by ~10%.
  • Early diagnosis and consistent management, including antihypertensive medications, are critical for long-term cardiovascular health.

Self-Monitoring Tips

  • Measure BP twice daily (morning and evening) with validated devices.
  • Avoid smoking, caffeine, or exercise 30 minutes before measurements.