Pharmacology

Overview P450 Inducers P450 Inhibitors St. John’s WortPhenytoinBarbituratesRifampinGriseofulvinCarbamazepine EfavirenzModafinilCyclophosphamideBroccoli, brussel sprouts, and char-grilled meatsEthanol Tricyclic

Overview Ganglionic Blockers Ganglionic blockers, also known as ganglionic blocking agents, are a class

Overview – Central and Peripheral Nervous System ACh receptors What Is the Central and

Overview Elimination of drugs  rate of elimination is rate of disappearance of active molecules from

Overview What is Phase I Metabolism? Phase I metabolism refers to the initial metabolic

Competitive vs. noncompetitive antagonist (Pharmacodynamics) Agonist vs. partial agonist Synergism & Potentiation Overview Pharmacodynamics

Overview (Efficacy vs. Potency) Efficacy vs. Potency Efficacy and potency are two important concepts

Snapshot Introduction (Salicylate/Aspirin Overdose) Presentation Studies Differential Treatment Treatment for salicylate overdose typically involves

Overview Therapeutic Index The therapeutic index (TI), also known as the therapeutic window, is

Introduction – Autonomic Pathways The autonomic nervous system (ANS) is the part of the

Alpha-Blockers Drug Clinical Applications Toxicity Nonselective α-Blockers Phenoxybenzamine (irreversible, preferred)   • Pheochromocytoma • High catecholamine states

Overview – Drug Excretion Weak acids and bases Drug Excretion Drug excretion refers to