Cardiac Tumors

Snapshot

  • A 56-year-old man presents to his primary care physician for shortness of breath and episodes of lightheadedness. He says that his symptoms progressively worsened over the course of months. He recalls producing bloody sputum a few weeks ago and fainting for a few seconds yesterday night. Medical history is unremarkable. He denies alcohol, illicit drug, or cigarette use. Physical examination is remarkable for a “tumor plop” appreciated during diastole. An echocardiogram is performed and shows a left intra-atrial pedunculated mass. (Atrial myxoma)

Introduction

  • Cardiac tumors
    • these can be divided into
      • primary cardiac tumors
        • myxoma (most common primary cardiac tumor)
          • occur mainly in the left atrium
        • rhabdomyoma
      • metastatic tumors
        • most common cardiac tumors overall
  • primary cardiac tumors are extremely rare and are more likely to be benign

Cardiac Tumors

Cardiac Tumors
TypePathologyComment
MyxomaMost commonly found in the atriumpreferably in the fossa ovalis of the atrial septum PresentationConstitutional symptoms (fever, weight loss, and fatigue)commonly due to IL-6 production by the myxomaCan be friable and cause systemic embolization leading to stroke and other ischemic eventsDiastolic “plop” may be auscultatedMasses can be pedunculatedthis mass can make its way towards the atrioventricular valve opening during systole, resulting in an obstruction (which can lead to syncope) and damaging the valve leaflets echocardiography will show pedunculated massHistologycomplex structures surrounding blood vessels and may appear as cords, rings, nests, or poorly formed glandsabundant mucopolysaccharide ground substanceconsists of chondroitin sulfate and hyaluronic acidconsists of stellate or globular myxoma cellseosinophilic cytoplasmill-defined cell bordersoval nucleusindistinct nucleiopen chromatinMost common primary heart tumor in adultsEchocardiography can identify the tumorSurgery is the definitive treatment
Rhabdomyoma Approximately 50% of cases are associated with tuberous sclerosis Histology”spider cells”hamartomatous growthsMore common in pediatric patients and typically found within the first year of life