Snapshot
- A 33-year-old man presents to his primary care physician for a rash involving his left leg. His symptoms began approximately 7 days ago, when he noted a rash. He is unsure if he had any trauma to the leg but states he has had mild fevers. The patient is allergic to penicillin. His temperature is 100°F (37.7°C), blood pressure is 138/88 mmHg, pulse is 98/min, and respirations are 18/min. Physical examination is notable for an erythematous, edematous, and warm lesion involving the left ankle that is tender to palpation. He is started on clindamycin. (Cellulitis)
Introduction
- Mechanism of action
- reversibly binds to the 50S ribosomal subunit, impairing bacterial protein synthesis
- impairs the transpeptidation reaction within the ribosome
- reversibly binds to the 50S ribosomal subunit, impairing bacterial protein synthesis
- Clinical use
- anaerobic infections (e.g., aspiration pneumonia, oral infection, and lung abscess)
- Bacteroides spp.
- Clostridium perfringens
- Fusobacterium spp.
- staphylococci
- viridans group streptococci
- Streptococcus pyogenes
- Streptococcus pneumoniae
- group A streptococcal infection
- anaerobic infections (e.g., aspiration pneumonia, oral infection, and lung abscess)
- Adverse effects
- fever
- diarrhea