Clomiphene

Mechanism

Partial estrogen receptor agonist
- See Female Hypothalamic-Pituitary Axis topic
Acts specifically in hypothalamus which antagonizes normal negative feedback inhibition
Results in an ↑ release of LH and FSH from pituitary
stimulates ovulation

Indications

Infertility
PCOS

Toxicity

Ovarian enlargement
Multiple birth pregnancy
Visual disturbances
Hot flashes

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Clomiphene

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