Introduction
- Definition
- manifestation of chronic rejection in lung transplant (and allogenic bone marrow transplant)
- involves small bronchioles
- obstructive pattern on PFTs (reduced FEV1/ FVC)
- major problem in lung transplant patients
- vasculature is relatively unaffected unlike other examples of chronic organ rejection
- e.g. kidney
- vasculature is relatively unaffected unlike other examples of chronic organ rejection
- Other etiologies
- viral infections
- collagen vascular diseases
- toxic fumes
- rheumatoid arthritis
- manifestation of chronic rejection in lung transplant (and allogenic bone marrow transplant)
- Pathophysiology
- lymphocytic inflammation of bronchiolar wall
- damage replaced by fibrous tissue
- progressive reduction in diameter of small airway lumens