Esophagitis

Corrosive Esophagitis

• Caused by ingestion of strongly acidic or basic chemical
  • Lye, HCl
• Results in
  • esophageal perforation
• esophageal stricture formation

Infectious Esophagitis

• Commonly seen in AIDS patients
• May be viral or fungal
  • HSV-1
    • mutiple punched-out ulcers throughout esophagus with normal mucousa
      • ulcers can coalese and form “black esophagus”
    • histology will show eosinophilic intranuclear inclusions (Cowdry type A) and multinucleated squamous cells surrounding the ulcers on biopsy
  • CMV
    • single, large, shallow, linear ulcer
  • Candida 
• Odynophagia is main symptom