Movement Abnormalities

Snapshot

  • A 65-year-old man is brought to his primary care physician by his wife due to “abnormal movement.” She states that her husband appears depressed and has a tremor that occurs at rest. She also reports that he “moves very slowly.” The patient says that he has no current concerns. Past medical history includes hypertension, which is treated with hydrochlorothiazide. On physical exam, there is a right-sided 3-5 Hz resting “pill-rolling” tremor and cogwheel rigidity of the right upper extremity. On gait testing, the patient takes short steps and has a stooped posture. (Parkinson disease)

Introduction

  • Abnormal movements can result from impairment of the
    • upper and lower motor neurons
    • motor cortex
    • motor association cortex
    • cerebellum
    • basal ganglia
    • e.g., Wilson’s disease 
Movement Disorders
TypeComments
TremorEssential tremor presentationmost commonly affects the hands or armstypically bilateralcan cause functional impairmentthe tremor worsens with stress and improves withalcoholβ-blockersoften familial with anautosomal dominant inheritance patterntreatmentβ-blockers (e.g., propranolol) primidonePhysiologic tremorpresentationaffects all people but may become visible withcaffeinebeta-agonistshypoglycemiaanxietyexcitementalcohol and opioid withdrawalthyrotoxicosistreatmentdependent on etiologye.g., decrease caffeine intakeIntention tremor presentationappendicular ataxiawhen using their extremity towards a target there isirregular and oscillating moevmentassociated with cerebellar disordersResting tremor presentationtremor that occurs when the limbs are relaxedcan be best observed when distracting the patienttremor improves when the patient moves their limbscan be described as “pill rolling”this is an important of Parkinson’s disease
DystoniaPresentationsustained or slowed abnormal positions of the limb, trunk, or faceexamples of dystonia includetorticollisblepharospasmspasmodic dysphoniawriter’s crampBelieved to be due to dysfunction of thebasal ganglia Treatmentmany cases have a good response tobotulinum toxin injection
MyoclonusPresentationrapid muscular jerk that can be due to multiple causesseizuree.g., juvenile myoclonic epilepsyanoxi brain injuryencephalitistoxic or metabolic encephalopathyparaneoplastic syndromesCreutzfeldt-Jakob disease 
Chorea Presentationdance-like involuntary movement An important cause of chorea isHuntingon’s disease 
Athetosis Presentationwrithing and twisting movementof the limbs, face, and trunkthat can merge with chorea to formchoreoathetosis
Ballismus Presentationrotatory or flinging movement of the proximal limb musclesThe most common type of ballismus ishemiballismuscontralateral extremity flinging movement secondary toa lesion (e.g., lacunar stroke) to the subthalamic nucleus
TicsPresentationa sudden and brief movement that is preceded byan urge that is then relieved afterthe movement is performedThe types of tics includemotor ticsvocal ticse.g., barking-like noises and coprolaliaAn important syndrome to know isTourette’s syndrome