Pathologic RBC Forms

Overview

TypeExampleAssociated Pathology
Acanthocyte (spur cell)https://upload.medbullets.com/topic/111007/images/acanthocyte.jpg Liver disease, abeta lipoproteinemia  
Basophilic stipplinghttps://upload.medbullets.com/topic/111007/images/slide003basostip2.jpg Lead poisoning
Bite cellhttps://upload.medbullets.com/topic/111007/images/images..jpg G6PD deficiency
Elliptocytehttps://upload.medbullets.com/topic/111007/images/eliptocyte.jpg Hereditary elliptocytosis
Macro-ovalocytehttps://upload.medbullets.com/topic/111007/images/macro-ovalocyte-100x-website-arrow.jpg Megaloblastic anemia, marrow failure
Ringed sideroblastshttps://upload.medbullets.com/topic/111007/images/ringed_sideroblasts.jpg Sideroblastic anemia
Schistocyte, helmet cellhttps://upload.medbullets.com/topic/111007/images/schistocyte.jpg DIC, TTP/HUS, traumatic hemolysis
Schizonthttps://upload.medbullets.com/topic/111007/images/pf_schizont_thinb.jpg Malaria 
Sickle cellhttps://upload.medbullets.com/topic/111007/images/sickle.jpg Sickle cell anemia
Spherocytehttps://upload.medbullets.com/topic/111007/images/spherocytes.jpg Hereditary spherocytosis, autoimmune hemolysis
Teardrop cellhttps://upload.medbullets.com/topic/111007/images/teardrop.jpg A result of mechanical damage when RBC squeezes through fibrosis to exit bone marrow
Target cellhttps://upload.medbullets.com/topic/111007/images/target.jpg Asplenia, liver disease, thalassemia, HbC disease 
Heinz bodieshttps://upload.medbullets.com/topic/111007/images/heinz.jpg Due to oxidation of hemoglobin sulfahydryl groups to disulfide bonds resulting in hemoglobin precipitationSplenic macrophages remove precipitated hemoglobin resulting in bite cellsAssociated with G6PD
Howell-Jolly bodieshttps://upload.medbullets.com/topic/111007/images/howelljolly.jpg Basophilic nuclear remnants found in RBCs associated with functional hyposplenia or