Penis Cancer

Introduction

• May have carcinoma in situ (CIS) or squamous cell carcinoma (SCC)
  • carcinoma in situ
    • Bowen’s disease
      • leukoplakia on the shaft of the penis or scrotum
      • peak incidence > 50 years
      • associated with HPV 16
      • minority of cases progresses to SCC
    • Erythroplasia of Queyrat
      • erythroplakia on the glans/prepuce
      • only the location distinguishes Bowen’s from Queyrat’s
    • Bowenoid papulosis
      • multiple papular lesions
      • affects at a younger age than Bowden/Queyrat
      • associated with HPV 16
      • does not progress to SCC
  • Squamous cell carcinoma (SCC)
    • more common in Asia, Africa, and South America
    • most common sites are prepuce/glans
    • commonly associated with
      • HPV 16 and 18
      • smoking
      • lack of circumcision  
• increases risk only if man is not hygienic

Prognosis, Prevention, and Complications

• Metastasis
  • SCC may seed to inguinal and iliac nodes