Platinum Analogs

Cisplatin and Carboplatin

Platinum Analogs

Mechanism
- crosslinks DNA
  - platinum atom binds to DNA bases
Clinical use
- testicular cancer
- bladder cancer
- ovarian cancer
- lung cancer
Toxicity
- nephrotoxicity
  - prevent with
    - amifostine
      - free radical scavenger
    - hydration
- deafness
  - acoustic nerve damage