Proton Pump Inhibitors

Omeprazole

• Other agents: lansoprazole and pantoprazole
• Mechanism
  • irreversibly inhibits H+/K+-ATPase in gastric parietal cells   
    • H+/K+-ATPase is a primary active transporter
• Clinical use
  • peptic ulcer disease
    • well-documented in literature as most effective agent 
  • gastritis
  • GERD
  • Zollinger-Ellison syndrome
  • Eradication of H. pylori
• Toxicity 
  • P-450 inhibitor