| Mechanism |
| Androgen receptor agonist |
Indications
- Hypogonadism
- promotes development of male secondary sex characteristics
- Anabolism
- promote recovery after severe burn or injury
- ER-positive breast cancer
- ↑ testosterone has a negative feedback on LH/FSH leading to ↓ estrogen release
- testosterone not administered directly
- exemestane given which is an aromatase inhibitor
Toxicity
- Masculinization in females
- Testicular atrophy in males with
- decreased gonadotropin-releasing hormone
- decreased luteinizing hormone
- decreased follicle-stimulating hormone
- decreased sperm count
- increased estrogen
- Premature closure of epiphyseal plates in adolescents
- Worsening of lipid profile
- ↑ LDL, ↓ HDL
- reason men typically have worse lipids than women
- Hepatic adenoma
- benign mass that can rupture
- cause of sudden hypotension in a weightlifter (presumably abusing steroids)
- Erythrocytosis